Biosensors are nowadays being developed with lots of utilities because these provide specificity and sensitivity. These are being prepared by various companies to help researchers and laboratories to separate proteins from biological fluids. In the process of such separation, the biochips are having important role. These are rather used in SPR technology, where resonance is captured by sensors for getting the wavelengths on the computer screens. In this particular technology, gold chip is put inside the spectrometer, which will be useful in detecting the oscillations generated from molecules plated on the surface. These biochips are being used in plenty of ways nowadays for detection of various macro and micro molecules.

€ Improving resonance spectrum with high quality gold plating

In order to get the most out of these SPR spectrometers, the resonance has to be captured from plates. It has been observed that gold plating helps in better resonance of various separated proteins. To improve the efficiency of the gold chip, it is to be laid down on silicon based surfaces. Due to the refractive index of the gold medium, there is a change in the light angle, which can be checked by the biosensors. As the realisation about the advantages of gold plates increase, many laboratories are using these techniques to create better SPR technologies.

€ Frequent usage of gold in microarray chips for detecting proteins

Mostly, the gold chip is nowadays used in SPR sensor instruments for detecting the proteins. When the biological mixture is applied on the surface, there is adsorption onto these plates, which then oscillate the metal molecules. Since gold molecules are highly sensitive to such physical and chemical changes, these are being fabricated to be more stable and hydrophilic for proteins. They can allow the deposition of plenty of molecules on their surface and cause their detection by innovative means.

€ Increasing stability and lowering toxicities of gold plated surfaces for detection

When surface Plasmon resonance technology is being used, the primary concern with protein biochip is its stability to various biological fluids and laser beams. Gold is supposed to provide the stability and at the same time allows for lower toxicities and reactivity. Further enhancement of the stability is by adding other polymers, which can improve the results detected by sensors. For protein detection, these chips are of much importance and presently being considered by many laboratories. In coming years, there will be much more demand of the sensors and protein biochip, which make use of gold elements with the incumbent advantages.

€ Adding immobilisation properties to tagged proteins for improved chip functions

Variety of proteins can be attracted towards the protein biochip by improving their immobilisation after binding. This is an added advantage to the gold chip, which is a sensitive and specific process. The immobilisation is done by increasing the covalent bonding between molecules of proteins and the tags or polymers on the microarray surfaces. These technologies are frequently incorporated with SPR in biomedical research, diagnosis and therapeutic procedures. Such techniques are sure to improve the end results and can lead to better detection and diagnostic methods.