Conclusion
Interval CRCs account for 2.8–4.9% of all sporadic CRCs, with a significantly higher proportion being proximal in origin. Several clinical-related (advanced age, family history of CRC, higher comorbidities, presence of diverticular disease, and history of polypectomy), endoscopy-related (low polypectomy rate, low procedural completion rate, procedural performance by a non-gastroenterologist) and biology-related (MSI, CIMP positivity) risk factors are associated with interval CRCs. With improvements in quality of colonoscopy to decrease miss rates and increase complete polypectomy rates as well as better understanding of tumor biology, the risk of interval CRCs should decrease.