Implications for Practice

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  A number of factors may contribute to the development of irritant contact dermatitis (ICD) at peripherally inserted central catheter (PICC) insertion sites, necessitating an in-depth history and assessment of the morphology, pattern, and site of the skin lesions.
  
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  Burning, stinging, or itching at the PICC site when applying chlorhexidine gluconate antiseptic cleanser may be an early sign of ICD before a visible rash even appears. The proactive elimination of the suspected offending agent often resolves the skin irritation.
  
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  Early recognition and management of ICD, while adhering to best practices in central line and skin care, can improve the patient care experience and prevent complications related to central lines.