Abstract and Introduction
Abstract
Aims Isolated aortitis (IA) is a newly recognized condition, but its differentiation from Takayasu arteritis (TA) is still a challenge. This study aims to explore the characteristics of IA.
Methods The clinical and pathological data of 965 cases with excised ascending aortas were obtained by chart and slide review. IA cases were compared with TA cases and examined for CD3, CD4, CD8, CD20, CD68, CD138 and IgG4 of the infiltrates using immunohistochemistry.
Results 24 cases of IA and eight cases of TA were identified. IA cases tended to be older than TA cases (mean 46.3 vs 33.9 years). Both groups had the same male/female ratio (1.0). IA cases tended to have a bigger aortic diameter (mean 59.7 vs 47.6 mm), statistically less intimal thickening (mean 678 vs 1101 μm), fewer lesions outside the ascending aorta (8% vs 100%), a lower erythrocyte sedimentation rate (mean 14.6 vs 27.0 mm/h) and more active aortitis (75.0% vs 62.5%) than TA cases. The number of CD3+ cells was equal to CD20+ cells in the media but fewer than CD20+ cells in the adventitia of IA cases. Their CD4/CD8+ ratio ranged from 1.0 to 1.8 while the number of CD68+ macrophages varied largely. IgG4+ cells ranged from 0 to 40 (mean 4) cells/HPF and the IgG4+/CD138+ ratio ranged from 0 to 0.36 (mean 0.06) in IA cases.
Conclusions Cases of IA tend to have more histologically active inflammation except for a relatively normal erythrocyte sedimentation rate, localised lesions and milder intimal fibrosis than cases of TA. IgG4 abnormality may not be the main cause of IA.
Introduction
Isolated aortitis (IA) has increasingly been recognised as a new entity of non-infectious aortitis. This kind of aortitis is usually localised in the ascending aorta and lacks infection, systemic disorder or rheumatological abnormalities. Its prognosis appears to be good after surgery. Unlike Takayasu arteritis (TA), it is not usually treated with corticosteroids. To our knowledge, the comparison between IA and other common non-infectious aortitis such as TA and giant cell aortitis has not been well studied because of their relative rarity and difficulty in diagnosis among pathologists. Furthermore, the aetiology of IA is still unknown despite the finding of IgG4 abnormality in some cases. In order to improve our understanding of IA, we identified patients with IA among those with chronic ascending aortitis in a large aortic surgery centre in China and re-examined the clinical and histopathological changes including IgG4 secretion of plasma cells in these patients compared with patients with TA.