The leaders of the Chattan Confederation, Clan MacKintosh fought in the center of the Jacobite line and suffered heavily in the fighting. As the "Forty-Five" began, the MacKintoshes were caught in the awkward position of having their chief, Captain Angus MacKintosh, serving with government forces in the Black Watch. Operating on her own, his wife, Lady Anne Farquharson-MacKintosh, raised the clan and confederation in support of the Stuart cause.

Assembling a regiment of 350-400 men, "Colonel Anne's" troops marched south to join the Prince's army as it returned from its abortive march on London. As a woman she was not permitted to lead the clan in battle and command was assigned to Alexander MacGillivray of Dunmaglass, Chief of Clan MacGillivray (part of the Chattan Confederation).

In February 1746, the Prince stayed with Lady Anne at the MacKintosh's manor at Moy Hall. Alerted to the Prince's presence, Lord Loudon, the government commander in Inverness, dispatched troops in an attempt to seize him that night. Upon hearing word of this from her mother-in-law, Lady Anne warned the Prince and sent several of her household to watch for the government troops. As the soldiers approached, her servants fired on them, screamed the war cries of different clans, and crashed about in the brush. Believing they were facing the entire Jacobite army, Loudon's men beat a hasty retreat back to Inverness. The event soon became known as the "Rout of Moy."

The following month, Captain MacKintosh and several of his men were captured outside of Inverness. After paroling the Captain to his wife, the Prince commented that "he could not be in better security, or more honorably treated." Arriving at Moy Hall, Lady Anne famously greeted her husband with the words "Your servant, Captain," to which he replied, "Your servant, Colonel," cementing her nickname in history. Following the defeat at Culloden, Lady Anne was arrested and turned over to her mother-in-law for a period. "Colonel Anne" lived until 1787, and was referred to by the Prince as La Belle Rebelle (the Beautiful Rebel).